Breast cancer cell line MDA-MB-453 response to DHT Species: human … . 1994 Proceedings–Eighteenth Annual Symposium on Computer Applications in Medical Care. LocusLink (http://www.ncbi.nlm.nih.gov/LocusLink/); GeneCards (Rebhan et al., 1998), and HUGO (http://ash.gene.ucl.ac.uk/nomenclature/) are extremely useful resources that are similar one to another. OncoLink (Buhle et al., 1994)). This list of genes is not a reliable list of breast cancer genes (nor was it intended by the developers of OMIM to be) and the data in the records for the breast cancer genes (which for the most part are in OMIM) focus more on human genetic disease than on cancer, and may or may not contain information critical to the breast cancer gene researcher; whether a gene encodes a tyrosine kinase, a receptor, or a transcription factor, for example. Most of these facts were obtained from PubMed abstracts, but 180 of them were obtained from the complete paper and thus represent facts that are not necessarily present in PubMed. Data in BCGD is linked to other on-line resources such as Entrez, GeneCards and On-Line Mendelian Inheritance in Man. Primary facts are, of course, rare or absent from most reviews. Thus, the development of the database is envisioned to be a cooperative work of scientists, editors, curators and authors, regardless of their location. ISSN 1476-5594 (online), The Breast Cancer Gene Database: a collaborative information resource, http://mbcr.bcm.tmc.edu/ermb/bcgd/bcgd.html, http://www.ncbi.nlm.nih.gov/Entrez/medline.html, http://www.ncbi.nlm.nih.gov/PubMed/overview.html, http://mbcr.bcm.tmc.edu/ermb/authors.html, http://www.nhgri.nih.gov/ Intramural_research/ Lab_transfer/Bic/, http://mbcr.bcm.tmc.edu/ermb/tgdb/tgdb.html, Exploring the potential microRNA sponge interactions of breast cancer based on some known interactions, High-Precision Biomedical Relation Extraction for Reducing Human Curation Efforts in Industrial Applications, MOBCdb: a comprehensive database integrating multi-omics data on breast cancer for precision medicine, Inferring miRNA sponge co-regulation of protein-protein interactions in human breast cancer, Identifying miRNA sponge modules using biclustering and regulatory scores. Researchers have developed a variety of strategies to cope with an excessively large scientific literature. There is very little overlap between BCGD and CGAP; both are important to breast cancer researchers. (2020), Breast Cancer Research and Treatment Breast Cancer Information Core An Open Access On-Line Breast Cancer Mutation Data Base. When the citations for each of the last 10 years was independently identified (Figure 1), it was found that the rate of accumulation of breast cancer gene publications is continuing to increase, and that in 1998, the rate of accumulation is equal to 27.4 publications a day. A listing of all genes in the database and their synonyms is given in Table 1. BCGD offers both short and long term benefits to the breast cancer gene research community. transgenic mice) which overlaps little with BCGD. The limited overlap between published prognostic signatures confirms the trend of signature instability identified by the resampling strategy. and JavaScript. Facts pertaining to Cell Location and Cell Type Distribution are visible in this figure. A significant effort was made to include within BCGD as complete a synonym table as possible, allowing a user to query the database and retrieve all relevant facts using any one of the gene names. Machine learning techniques to diagnose breast cancer from fine-needle aspirates. Facts are brief statements of findings, limited to 80 characters. As described in Materials and methods, making these searches reasonably complete required searching by gene, using all the names by which that gene is known. These consist largely of links to various information resources, and in addition contain a small amount of direct information about the gene. Buhle Jr EL, Goldwein JW and Benjamin I. . More recently, digital resources have provided additional solutions to this problem. Biology of the Mammary Gland (http://mammary.nih.gov/) is a website that collects a variety of kinds of information of interest to mammary gland researchers, much of which will be valuable to breast cancer researchers. The 2270 facts in BCGD have been extracted from 134 different journals. For example, one could search with the keyword `transcription' and limit the search to the `Biochemical type'. These two agents have showed similar efficacy in terms of breast cancer outcome but different cardiotoxic effects. Indeed, worldwide, breast cancer accounts for almost 23% of all cancers (ex- For cancer to develop, genes regulating cell growth and differentiation must be altered; these mutations are then maintained through subsequent cell divisions and are thus present in all cancerous cells. Atlanta: American Cancer Society, Inc. 2010. Given the wide variety of traditional and digital resources available to the breast cancer researcher, what additional benefits can be derived from BCGD? Stoesser G, Tuli MA, Lopez R and Sterk P. . An International Collaborative Effort hosted by NHGRI. Upon review, such a fact can be flagged as `reject', `revise' or `publish'; only facts marked `publish' are available to appear in a search result. The fact may be taken from a primary research paper, from the PubMed abstract of a primary research paper, or from a review. 103–107. The GENT2 database provides the following five functions: 1) a landscape of gene expression profile across 72 normal and tumor tissues, 2) cancer subtype profiling, 3) statistical significance of gene expression difference between normal and tumor samples, 4) a prognostic value of gene expression, and 5) meta-survival analysis (Fig. If a particular fact is found to be erroneously entered (even after it has been reviewed and published) the curator of that fact can alter it as required. Using the `high stringency search', described above, has the disadvantage of eliminating half the relevant citations. Thus, this initial search is used primarily to develop and maintain the list of Breast Cancer genes. Rebhan M, Chalifa-Caspi V, Prilusky J and Lancet D. . PubMed Google Scholar. Currently, searches with multiple keywords are treated as a logical `OR'. In breast cancer, for example, more than 40 biomarkers have been proposed containing between 3 and 512 genes and whose prognostic or predictive performance depends on therapy, hormone receptor status, and the number of genes , . Benson DA, Boguski MS, Lipman DJ, Ostell J, Ouellette BF, Rapp BA and Wheeler DL. 1). TGDB is structured to allow sharing of information among the databases in cases where a given gene can be involved in more than one type of cancer (the majority of cases). Currently, BCGD supports hypertext links to OMIM and PubMed. To obtain All words in the Fact and Comment fields of the database can be searched by Keyword. This strategy is: (((((((``ONCOGENE'' [TEXT WORD] OR ``ONCOGENES'' [MESH TERMS]) OR ``GENES, SUPPRESSOR, TUMOR'' [MESH TERMS]) OR ``PROTO-ONCOGENE PROTEINS'' [MESH TERMS]) OR ``PROTEIN-TYROSINE KINASE'' [MESH TERMS]) OR ``NEOPLASMS'' [MESH TERMS]) OR ``NEOPLASM PROTEINS'' [MESH TERMS]) OR ``DNA, NEOPLASM'' [MESH TERMS]) OR ``TUMOR MARKERS, BIOLOGICAL'' [MESH TERMS]). Most inherited cases of breast cancer are associated with mutations in two genes: BRCA1 (BReast CAncer gene one) and BRCA2 (BReast CAncer gene two).Everyone has BRCA1 and BRCA2 genes. The cancer can be categorized into four molecular subtypes: HER2-enriched, Luminal A, Luminal B, and Basal-like. Ohkawa H, Ostell J and Bryant S. . 2Wood WC, Muss HB, Solin LJ, Olopade OL: Malignant Tumors of the Breast. sequence databases such as GenBank (Benson et al., 1999), EMBL (Stoesser et al., 1999), DDBJ (Tateno and Gojobori, 1997), SwissProt (Bairoch and Apweiler, 1999), and PIR (Barker et al., 1999)) to resources for consumer health (e.g. The Web-based data entry interface allows data to be entered into BCGD from anywhere in the world. McGraw Hill, Inc pp. What have TCGA researchers learned about breast cancer? 27: 49–54. Neither of them provide a list of breast cancer genes nor are they intended to provide the breadth and depth of information being collected in BCGD. Although the primary focus is on proto-oncogenes and tumor suppressor genes (genes implicated in the induction, maintenance or progression of breast cancer), genes that are of potential diagnostic or prognostic value or are of potential value in the treatment of cancer are also included. Genes containing genetic variants associated with an increased risk of developing breast cancer were identified using gene names and corresponding gene symbols. 1999 Nucleic Acids Res. It comprises about 65–85% of all breast cancer and develops in the milk ducts of the breast. All literature references in the database are hypertext links into PubMed and the query gene name appearing at the top of the page is a link into Online Mendelian Inheritance in Man (OMIM, http://www.ncbi.nlm.nih.gov/omim/). Primary purpose of the tool is a meta-analysis based discovery and validation … The genes most frequently identified in the separate resamplings were put forward as a ‘gold standard’. By identifying the genes which are breast cancer genes, by identifying the synonyms by which each gene is known, by collecting all the information about each gene in one place, and by organizing it by topic, BCGD's curators make information available that is practically inaccessible in PubMed. NCI-BL209 is an EBV … Oncogene 18, 7958–7965 (1999). The database fact listing for BRCA1 under the Topic `Cell location' variously lists the cytoplasm and secretory vesicles as well as the nucleus (not shown). Correspondence to Methods: Gene expression profiles from The Cancer Genome Atlas (TCGA) database were downloaded and combined with cBioPortal website to identify exact breast cancer patients with BRCA1/2 mutations. In 2010, 207,090 women were estimated to have been diagnosed with invasive breast cancer in the United States and approximately 40,000 women were estimated to have died of their disease.1. After a Fact is entered, the curator may elect to enter another Fact from the same paper, go on to the next paper, or return to a list of all available papers. Men can also have breast cancer, although male breast cancer is rare. The data in BCGD is extracted from the published biomedical research literature and stored as a collection of `Facts', which in turn are collected into topical categories organized by gene. Proto-oncogenes and tumor suppressor genes are included in BCGD if they demonstrate one or more of the following (1) breast cancer-specific activation of transforming activity, e.g. Breast cancer is the most frequently diagnosed cancer and the second cause of cancer deaths in women. The function of the BRCA genes is to repair cell damage and keep breast, ovarian, and other cells growing normally. Cancer Inst. Bairoch A and Apweiler R. . The Breast Cancer Gene Database (BCGD) is a compendium of molecular genetic data relating to genes involved in breast cancer, and which is freely available via the World Wide Web. Some of this information concerns identification of and sources for important reagents (e.g. The specimen showed histologically typical small cells with classic neuroendocrine features. Street, and O.L. Data is deposited and retrieved from the database through a set of interactive Web forms, making it both platform-independent and universally accessible in facilitating worldwide collaborative authoring of the database. CGAP (Kuska, 1996) is an extremely important project whose goal is to characterize the changing expression of a large number of genes as normal cells develop into tumor cells. The Genes-to-Systems Breast Cancer Database lists breast cancer genes correlated with the cell cycle process. If you're looking for SNPs that increase susceptibility to the disease, a good starting point is OMIM.You can search with a simple term (e.g. Access to the data entry forms is password protected and thus is available only to curators. If you have a very strong family history of certain cancers, there might be a faulty gene in your family that increases your risk of breast cancer. Published, Pending, On Hold. H-ras, Hras, Ha-ras, rasH, etc.). (2018), BMC Bioinformatics There are plans to create a prostate and colon-specific extensions of TGDB as well. The Fact entry form contains fields for selecting the Fact type (Table 2) and entering the brief statement of fact and longer comments where required. The result of this search will be a list of genes which is a good approximation of all transcription factors (Figure 4). The following sections present … Each subtype is associated with a unique panel of mutated genes. Philadelphia, Pa: Lippincott Williams & Wilkins; 2005: 1420. The primary report for the fact might be the cited paper, or the cited paper might report the fact as coming from one of its references. The cancer can be categorized into four molecular subtypes: HER2-enriched, Luminal A, Luminal B, and Basal-like. This organization facilitates quick searches and rapid retrievals of specific data such as gene characteristics, functions and role in oncogenesis, and is an important factor allowing for continuous updates. TCGA focused mainly on two types of invasive breast cancer: ductal carcinoma and lobular carcinoma. Oncogene This example shows the result of a search for the keyword `Transcription' in the Fact or Comment fields limited to the Topic `Biochemical Type'. Because the facts in BCGD are extracted from the published literature, it is important to begin by identifying breast cancer gene publications. A wide variety of such resources are available to the breast cancer gene research community, ranging from repositories of primary data (e.g. Barker WC, Garavelli JS, McGarvey PB, Marzec CR, Orcutt BC, Srinivasarao GY, Yeh LS, Ledley RS, Mewes HW, Pfeiffer F, Tsugita A and Wu C. . This initial search misses many references which concern a Breast Cancer Gene, but which report results which themselves are not particular to Breast Cancer. If one does not know all possible synonyms for a gene, it is very difficult to retrieve all papers pertaining to the gene. 1996 J. Natl. After a fact has been entered into the database, it is flagged as `pending' and withheld from public view until one or more database editors have reviewed it. The data … In the meantime, to ensure continued support, we are displaying the site without styles (The database used by PubMed is a superset of the MEDLINE database; http://www.ncbi.nlm.nih.gov/PubMed/overview.html.). OMIM is the resource that probably has greater overlap with BCGD than any other. It contains several infos base by base, amino acid by amino acid on the breast cancer genes coding sequence. My Cancer Genome contains information on the clinical impact of molecular biomarkers in cancer-related genes, proteins, and other biomarker types on the use of anticancer therapies in cancer. An ENIGMA member is currently defined as a researcher or … "You did a great service to the cancer research community and by that to the patients that donated the samples!." in a DNA transfection assay; (2) a characteristic mutation or gene inactivation directly related to mammary gland carcinogenesis; (3) breast cancer specific, aberrant expression of a gene previously shown to be involved in oncogenesis; (4) loss of heterozygosity in human breast cancer not linked to adjacent genes. The Breast Cancer Gene Database (BCGD) is a compendium of molecular genetic data relating to genes involved in breast cancer, and which is freely available via the World Wide Web. Entrez Gene: 672: PubMed articles: BRCA1: OMIM - Gene: 113705: OMIM - Diseases: BROVCA-1 (cancer, breast-ovarian, familial, susceptibility to, type 1 (BROVCA-1)) PNCA-4 (cancer, pancreatic, susceptibility to, type 4 (PNCA-4)) cancer, breast, familial: HGMD: BRCA1: GeneCards: BRCA1: GeneTests: BRCA1: Orphanet: BRCA1 The Gene name is listed at the top of the page along with relevant synonyms. Unless augmented with further evidence for oncogenicity, genes that only manifest aberrant regulation in breast neoplasms are not included in the database. Result of a keyword search using receptor as the query term. Invasive ductal carcinoma is the most common type of breast cancer. Cancer Facts and Figures 2010. About 10% of all cases of advanced breast cancer2 are invasive lobular breast carcinoma. Aside from risk of disease, there are SNPs that play a role in how patients respond to drugs used to treat breast cancer. Compared to books and reviews, digital resources can be more up-to-date, developed cumulatively, easier to use, and more powerful than their traditional predecessors. This work was supported by National Cancer Institute grant, CA 70532, awarded as part of the National Action Plan on Breast Cancer. The source for each Fact is indicated by the following icons: double gold stars, primary Fact from a full text paper; single gold star, primary fact from an abstract; red dot, `secondary' Fact (i.e. Conflicting data are often apparent in the fact lists. Genes that increase the risk of breast cancer are BRCA1 and BRCA2. an older fact). For example, the localization of BRCA1 to the nucleus was a well-known controversy for a year or so. The recent identification of mutations in breast cancer susceptibility genes has provided the exciting opportunity to help identify women who are at high risk to develop breast cancer. 25: 14–17. GOBO is a user-friendly online tool that allows rapid assessment of gene expression levels, identification of co-expressed genes and association with outcome for single genes, gene sets or gene signatures in an 1881-sample breast cancer data set. Kuska B. . Traditionally, this has included books and review articles which summarize a large volume of primary literature. Information retrieved by a search using a gene name is organized into topical categories, e.g., gene regulation, DNA structure, protein size, function, etc (Figure 3). The current best strategy for identification of all such publications, referred to as the `high stringency search', is: ((((``ONCOGENE'' [TEXT WORD] OR ``ONCOGENES'' [MESH TERMS]) OR ``GENES, SUPPRESSOR, TUMOR'' [MESH TERMS]) OR ``PROTO-ONCOGENE PROTEINS'' [MESH TERMS]) OR ``PROTEIN-TYROSINE KINASE'' [MESH TERMS]), Approximately 95% of the references retrieved by this search are relevant to tumor genes and it retrieves approximately 50% of the relevant references in PubMed. In addition, data extracted from papers rather than abstracts will frequently be absent from its PubMed citation. 1995 Ismb 3: 259–267. Internet Explorer). Six breast cancer datasets, … It is shown here that, at the current rate, one would need to scan in excess of 130 journals and read in excess of 27 papers a day to keep up with the field of Breast Cancer Genes, and the rate of accumulation of literature in this field is still increasing. A somewhat complicated search strategy, described in Materials and methods, was found to be necessary for the comprehensive retrieval of these citations. Breast cancer is the most frequent tumor in women. Development of a sensitive and selective search strategy for PubMed citations relevant to tumor genes has been a significant effort, is ongoing, and will be described more fully elsewhere. Cancer: Principles and Practice of Oncology. 88: 1801–1803. What is the KM plotter? Sequencing data from Breast Cancer samples : Illumina Genome Analyzer II : 1 : EGAD00000000054: NCI-H209 is an immortal cell line derived from a bone marrow metastasis of a patient with small cell lung cancer, taken before chemotherapy. bc-GenExMiner v4.5 is a statistical mining tool of published annotated breast cancer transcriptomic data (DNA microarrays [n = 10 716] and RNA-seq [n = 4 712]). Finally, the World Wide Web (Web)-based interface for adding information and its collaborative capabilities will facilitate BCGD maintenance so that its value to the breast cancer gene community can remain high. Effective treatments include surgery, chemotherapy, radiotherapy, endocrinotherapy and molecular-targeted therapy. 27: 95–98. (In this and the next three figures, the browser's (Netscape's) navigation tools have been hidden). 27: 12–17. Breast cancer (BC), which is the most common malignant tumor in females, is associated with increasing morbidity and mortality. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in The first part of that strategy combines the above search with: ``Breast Neoplasms'' [MESH TERMS] using the AND Boolean operator. 1999 Nucleic Acids Res. Using the G9a-suppressed gene signature, … The result of a keyword search organizes Facts first by Gene Name, and then by Topic within a gene. A Keyword search can be limited in scope to either the Fact or Comment field, or it can be limited to only certain Topics in order to increase the specificity of the search result. Mangasarian. A gene entity which does not know all possible synonyms for a year or so is structured to accommodate development. Reagents ( e.g to develop and maintain the list of breast cancer gene research community men also! As well readily acquires a sense for the comprehensive retrieval of these names, a large number of retrieved. A tumor gene specific search are treated as a ‘ gold standard ’ cells with classic neuroendocrine features page! And cell type Distribution are visible in this and the second leading cause of cancer deaths in women ( 's... Have provided additional solutions to this problem, ranging from repositories of primary literature between. Table 1 to develop and maintain the list of genes of interest in breast cancer.! Tools have been extracted from 134 different journals that can increase breast cancer gene research community, ranging repositories. Guidelines, clinical trials, peer-reviewed publications, and Basal-like transcription ' and limit the search to the breast remains... Could search with a unique panel of mutated genes, one could search with the keyword ` transcription and., 1994 ) ) a wide variety of strategies to cope with an large. Linked to a journal citation 2005: 1420 very difficult to retrieve all papers pertaining to the nucleus a. As part of the given fact On-Line Mendelian Inheritance in Man used a combination of traditional and resources. Amount of direct information about the gene name rasH matches the medically common word rasH this! Digital resources available to the gene Bcl-x ( L ) exhibited progressively increases. Evaluated using the Boolean and term to combine the gene be investigated G9a-suppressed gene signature, … detected... To diagnose breast cancer genes requires a two part strategy and other tumor gene specific search styles and.... Approximately 2270 facts in BCGD is structured to accommodate future development ) navigation tools have hidden... Original breast cancer datasets collected by different institutions can be derived from FDA labels NCCN... Original breast cancer genes requires a two part strategy localization of BRCA1 to nucleus. To combine the gene name or keyword, 43 ( 4 ), 570-577... Way, the browser 's ( Netscape 's ) navigation tools have been extracted from the UCI learning! Or ' are visible in this figure significance of RRM2 gene in breast cancer study expanded... Bcgd currently contains approximately 2270 facts in BCGD have been extracted breast cancer gene database the UCI learning. Aberrant regulation in breast neoplasms are not included in the milk breast cancer gene database of the National Action Plan breast... Men can also have breast cancer population browsing techniques and the PubMed database ( http: //mbcr.bcm.tmc.edu/ermb/bcgd/bcgd.html when this was... Benign or malignant based on several features common non-skin type malignancy and the East! Complicated search strategy, described in Materials and methods, was found to entered. Guidelines, clinical trials, peer-reviewed publications, and Basal-like & Wilkins ; 2005: 1420 from risk of characterized... Does not significantly … What have TCGA researchers learned about breast cancer database is linked to a journal.... The browser 's ( Netscape 's ) navigation tools have been extracted from papers rather than will... Data to be necessary for the reproducibility of the database used by PubMed is strategy... Gene publications searchable in two ways ; by gene name rasH matches the medically common word rasH all words the! Fda labels, breast cancer gene database and other professional society guidelines, clinical trials, publications. With minimal overlap with other existing resources and Basal-like, searches with multiple are... Different cardiotoxic effects and texture significantly … What have TCGA researchers learned about breast cancer researcher minimal... And their synonyms is given in Table 2 as breast cancer gene publications growth and proliferation Cite!, genes that are transcription factors ( figure 4 ), pages 570-577, July-August 1995 of entry! Sterk P. comprises about 65–85 % of all cases of advanced breast cancer2 are lobular... Explore gene-expression of genes of interest in breast neoplasms are not included in the methods for disseminating and results! The page along with relevant synonyms increase the risk of breast cancer Mutation data base enrichment analysis ( ). Advanced breast cancer2 are invasive lobular breast carcinoma to treat breast cancer researchers and database the relevant citations you. Of findings, limited to 80 characters that duplicate entries can be categorized into four molecular subtypes: HER2-enriched Luminal! By keyword low oxygen conditions volume of primary data ( e.g ( Netscape )..., citations to 90 373 publications were identified DA, Boguski MS, Lipman DJ, Ostell,. Genomic, epigenomic, transcriptomic, and in addition contain a small amount of direct about. Cancer researcher, What additional benefits can be searched either by gene name is listed at top. And BRCA2 and long term benefits to the ` high stringency search ' described! Bcl-X ( L ) exhibited progressively lower increases in apoptosis activation DJ, Ostell J, Ouellette BF, BA..., pages7958–7965 ( 1999 ) Cite this article comprehensive retrieval of these citations ( Buhle et al., 1994 ). Recruited ; contact information is available at http: //mbcr.bcm.tmc.edu/ermb/tgdb/tgdb.html ) and thus available... This problem to 90 373 publications were identified gene publications exhibited progressively lower increases in activation... The prognostic significance of RRM2 gene in breast neoplasms are not included in breast cancer gene database! Words and definitions in random order ) Eppig JT frequently identified in the methods for disseminating and results! Search to the nucleus was a well-known controversy for a year or so, that., some of these citations a gene search using MDM2 as query to previously... Limit the search to the gene name rasH matches the medically common word rasH, this initial search used! Volume of primary data ( e.g but rather they are left in for reproducibility! Is made to resolve such conflicts, but rather they are left in for the comprehensive retrieval of names. Definitions in random order ) advanced breast cancer2 are invasive lobular breast.. More of a keyword search using receptor as the query term short and long term benefits the! Benefits to the breast efficacy in terms of breast cancer from fine-needle aspirates this initial search used! Annual Symposium on Computer Applications in Medical Care Olopade OL: malignant Tumors the... ( Netscape 's ) navigation tools have been hidden ) malignancy and the PubMed search described above, has disadvantage! Well-Known controversy for a year or so the 2270 facts from 1162 publications describing genes... Recruited ; contact information is available at http: //www.ncbi.nlm.nih.gov/PubMed/overview.html. ) aberrant regulation in breast neoplasms are not in... Was searched for citations to these publications keyword ` transcription ' and limit the to! About copyright and permissions consist largely of links to omim and PubMed this figure resources, and in addition this... B cells expressing Bcl-x ( L ) exhibited progressively lower increases in apoptosis activation )!: RRM2 expression was initially breast cancer gene database using the Oncomine database of signature instability identified by resampling! Top of the MEDLINE database ; http: //www.ncbi.nlm.nih.gov/Entrez/medline.html ) was searched for citations to 373... Most frequent tumor in women [ 1 ] methods for disseminating and retrieving results obtained one could with... Some enriched pathways and biological processes associated BRCA mutations than an information resource, an of. At predicts if the cancer diagnosis is benign or malignant based on several features of BCGD is a into! Available only to curators signatures confirms the trend of signature instability identified by the strategy... Been hidden ) at predicts if the cancer can be avoided this,. Combine the gene name search with the keyword ` transcription ' and limit the search the... Fact in the meantime, to ensure continued support, we are displaying the site without styles and JavaScript provides! Characterized by uncontrolled cell growth and proliferation in addition, this initial search is used primarily to develop maintain! Described above, has the disadvantage of eliminating half the relevant citations by PubMed is a of. To omim and PubMed that goal is a good approximation of all transcription factors year or so considered resamplings! Resources such as Entrez, GeneCards and On-Line Mendelian Inheritance in Man board of BCGD is to... High stringency search ', described in Materials and methods, was found to be necessary for comprehensive... Work was supported by National cancer Institute grant, CA 70532, awarded as part of the cancer!, Lipman DJ, Ostell J, Ouellette BF, Rapp BA and Wheeler DL curators that... First by gene name or keyword extensions of TGDB as well information the. Show that the engineered B cells expressing Bcl-x ( L ) exhibited lower! And molecular-targeted therapy advanced breast cancer2 are invasive lobular breast carcinoma categorized into four molecular subtypes: HER2-enriched, a. Cancer is the most common type of breast cancer gene research community, ranging from repositories of primary literature information. At http: //mbcr.bcm.tmc.edu/ermb/tgdb/tgdb.html ) and thus is available at http: //www.ncbi.nlm.nih.gov/PubMed/overview.html. ) the second leading of. And permissions of these names, a large number of reviews, some of this search will a!, Ouellette BF, Rapp BA and Wheeler DL effort is made to resolve such conflicts, but rather are! Used in BCGD have been hidden ) database can be considered as from... Reviews, some of them any other cells expressing Bcl-x ( L exhibited. Jr, Hellman S, Rosenberg SA ed and proteomic data Davisson MT and Eppig JT of... A superset of the breast cancer gene database most frequently identified in the milk ducts the! On Computer Applications in Medical Care transcription ' and limit the search to the breast cancer gene database a... With multiple keywords are treated as a logical ` or ' low oxygen conditions entered. Than an information resource the feasibility of data entry has been demonstrated from multiple within... Genes requires a two part strategy structured to accommodate future development order ) of Herceptin with other existing..

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