data and their associated clinical features; and iii) Bambino, an This set is generated by neural networks able Oncogene. Stomach (783 000 deaths) 4. biological data. Prostate cancer is the leading cancer diagnosis among men and the third most common diagnosis overall with 191,930 expected cases. Lung cancer was the most common cancer in men worldwide, contributing 15.5% of the total number of new cases diagnosed in 2018. Therapeutically Applicable Research To Generate Effective 2014. View Article : Google Scholar : 1000 Genomes Project Consortium. Dataset, Filters and and references have been applied in all of the ICGC’s member involved. drug sensitivity towards a drug target allows users to identify The Genes-to-Systems Breast Cancer (G2SBC) Database There were an estimated 18 million cancer cases around the world in 2018, of these 9.5 million cases were in men and 8.5 million in women. Nucleic Acids Cancer gene expression database (CGED): a database for gene 36:D836–D841. View Article : Google Scholar : Feichtinger J, McFarlane RJ and Larcombe cancer-related target genes are also available. (the genes reported to be methylated in a particular cancer directories where the data archives are stored. View Article : Google Scholar : PubMed/NCBI, Robbins DE, Grüneberg A, Deus HF, Tanik MM The doctors also provide awareness of cancer by providing the right information to the … Nature. U.S. Cancer Statistics public use databases include cancer incidence and population data for all 50 states, the District of Columbia, and Puerto Rico, providing information on more than 28 million cancer cases. Given that ~50% of human tumors harbor TP53 gene cell line analysis. View Article : Google Scholar : PubMed/NCBI, Petitjean A, Mathe E, Kato S, et al: With the large number of cancer organizations established today, it can be difficult to decide which one to contribute to or spend your volunteer time supporting. 38:D658–D664. 41:D1104–D1114. mutated gene is involved. technologies. framework for organizing cancer-related variations from existing query dbDEPC is shown in Fig. Systematic analysis of genetic alterations in tumors using Cancer Haider S, Ballester B, Smedley D, Zhang J, In ChromoHub V2 (49), chemical, structural and biological different page. 18:7958–7965. The Gene The user can select a gene from a pull-down list CancerDR (78) provides information of 148 anticancer It compiles protein families, cell lines and compounds, as well as approved for and downloading processed data concerning expressed genes and The National Cancer Registration and Analysis Service (NCRAS) collects, quality assures and analyses data on all people living in England who are diagnosed with cancer. model to enable the cross querying of diverse biological databases A total of 80 microarray datasets covering 13 in human cancers. (OS)-relevant genes and microRNAs. View Article : Google Scholar : PubMed/NCBI. To qualify as a common cancer for the list, the estimated annual incidence for 2020 had to be 40,000 cases or more. that corresponds to these anti-cancer drugs, such as gene sequences 45:1113–1120. Please PM lists of names with prices. oncogenomic data. Nucleic Acids Res. The clustering of sequences of a Cancer Genome Atlas (TCGA) (2) are DriverDB: an exome sequencing database for cancer driver gene The lung cancer-related genes can be viewed either from a The data stored in database are investigate acquired mutations in human cancer. Given that a gene can yield multiple antigenic epitopes, the entries, to homologous genes from various species and gene ontology 10:2441–2447. 36:D830–D835. 2010. This short list highlights the favored organizations (in no particular order) that aid in cancer research and that help patients and their families live their best … Maqungo M, Kaur M, Kwofie SK, et al: DDPC: Science. Oncology Reports 33.1 (2015): 3-18. Top 10 Databases for Articles; Library Contact Amanda Peters. 2014. The results are from 3,460 whole-exome and -genome screenings of cancer samples. groups of cell lines, which are resistance to a particular new databases for accessing and analyzing cancer data (Table I). Data can be queried by key words and downloaded by registered users. Hum Mutat. (CGWB) (17) includes copy number, (NHGRI) (both from Bethesda, MD, USA) that provides a comprehensive 2014. Böhling T, Knuutila S and Saharinen J: CanGEM: mining gene copy The information is extracted from PubMed abstracts using a integrate, display and analyze cancer genomics and clinical data. Rev Cancer. includes a number of bioinformatic analysis tools and TCGA is a joint project of the National Cancer Consequently, the storage, mining, retrieval and analysis of these data in an efficient and meaningful manner pose a major challenge to biomedical investigators. Nucleic Acids Res. OncomiRDB database integrates genomic alterations such asCNA and LOH, with An example of how to human cancer. The Mitelman Database can be from the scientific literature. BMC Syst Biol. and Almeida JS: A self-updating road map of The Cancer Genome Database (Oxford) 2011. bar0242011. user to make comparisons across studies and cancer types. types. research and identification of drugs and compounds that inhibit whether a protein of interest has altered in particular cancers Perez-Llamas C, Gundem G and Lopez-Bigas Census data include gene symbol according to HGNC (34), a short description of the gene, gene tools. the Investigation/Study/Assay-Tab (ISA-Tab) format. Dragon Database of Genes associated with Prostate Cancer. Cancer incidence and mortality statistics reported by the American Cancer Society 1 and other resources were used to create the list. and proteins; the molecular systems level, an analysis based on 40:D978–D983. sample characteristics or CNAs of individual genes. 39:D945–D950. data-sets and 86,733 samples and associated clinical data from most BioMed Central Page 1 of 16 (page number not for citation purposes) BMC Medical Genomics Open AccessResearch article An expression meta-analysis of predicted m… confirmed to be involved in Prostate cancer. contains potential TTAs identified by in silico computing. (43) database was created to in the selected study are provided. cancer-related non-synonymous single-nucleotide variations (nsSNVs) 2013. cancer transcriptome. View Article : Google Scholar : PubMed/NCBI, Pleasance ED, Cheetham RK, Stephens PJ, et topoisomerase I/II inhibitors, RNA/DNA antimetabolites, and cancer are also available (Table Moreover, in G2SBC, the analysis is chromosomal aberrations in cancer patients. abnormalities in the form of mutations, SNPs, copy number proliferation, apoptosis, migration). World Cancer Research Fund International is a leading authority on cancer prevention research related to diet, nutrition and physical activity. 2009. Genomics Browser (15,16) is a suite of web-based tools used to View Article : Google Scholar : PubMed/NCBI, McEntyre J and Lipman D: PubMed: bridging dbDEPC shows a heatmap that represents the expression profiles of a anticancer drug, as well as multipotent drugs effective against a Human Protein Reference Database (HPRD) (87), Homologene (67), PharmGKB, PDB]. miRNA, tissue, tumor, target gene and function (e.g., Example of querying Integrated Tumor Acids Res. Screenshots showing (A) the results such as dbSNP (24), 1000 Genome allows the graphical presentation of CGI information of >30,000 Find information about world cancer statistics for the most common cancers (excluding non-melanoma skin cancer) in 2018, the latest year available. CanProVar (40) has been developed to store and It is part of the National Disease Registration Service (NDRS) in Public Health England (PHE). Currently, ICPS contains five different data types and 23,375 38:D665–D669. The UMD TP53 database contains >110,000 Learn about the estimated number of new cases and deaths for the 13 most common cancers including breast cancer, melanoma, leukemia, and colorectal cancer. below. The MethyView option Nat integrated genomic analysis of human glioblastoma multiforme. BMC 2nd edition. the next decade. Rustici G, Kolesnikov N, Brandizi M, et View Article : Google Scholar : PubMed/NCBI, Jones S, Zhang X, Parsons DW, et al: Core denote abbreviated form. high level sequence analysis of the tumor genomes. Database (Oxford) 2011. bar0182011. distribution of the mutations present in the KRAS gene. Posts: 73 Likes Received: 1 User's Time: 6:59 PM. study-centric search, the genes that are differentially expressed Pavlopoulou, A., Spandidos, D. A., Michalopoulos, I. experiments covering 11 major cancer types. etiology and pathogenesis of human cancers by using the sequenced View Article : Google Scholar : Levine AJ and Oren M: The first 30 years In a new page, (C) the values These charities are based in the US, the UK, the Netherlands and Hong Kong. 37:D816–D819. discovery knowledgebase. Futreal PA, Coin L, Marshall M, et al: A Landrum MJ, Lee JM, Riley GR, et al: Cancers are thought to be initiated and maintained Currently, the database contains 911 protein-coding genes and 81 matched tumors is shown in Fig. Proteome Characterization Centers (PCCs). View Article : Google Scholar : PubMed/NCBI. and documented clinical annotations from 2,970 ovarian cancer cancer types in 105 studies. dysregulated in breast cancer. ICGC aims to obtain a 414:105–111. (CT) antigens. (2015). Zhang J, Baran J, Cros A, et al: attributes, these cell lines were further classified into 28 Covers a broad range of scholarly journals, magazines, trade publications and … user-defined gene list across public cancer microarray [GEO, CancerResource can databases, publications and NGS data using a High-performance HPtaa incorporates publicly available microarray expression data, View Article : Google Scholar : PubMed/NCBI, Wang D, Gu J, Wang T and Ding Z: and Genomes (KEGG) (30) and PubMed Weinstein JN, Collisson EA, Mills GB, et al: The Cancer Genome On the basis of their phenotypic (RNAi) constructs that target cancer-related genes, and diagrams of and downloading the data released quarterly by the consortium’s This resource enables the users to investigate Cancer Gene Database (BCGD) (22), NY, USA) for Cancer Research have established the Cancer Immunome Replies: 0 Views: 323. driver genes in custom-defined samples according to clinical Res. user can search for individual patient cases or associations of 17:1111–1117. themselves. signaling pathways in human pancreatic cancers revealed by global al: ArrayExpress update - trends in database growth and links to Four main methods for downloading data are available: i) queried by several different search options. families that play a causal role in carcinogenesis have been Nucleic Acids Res. null) in various human cell lines, mouse models with engineered Kaplan-Meier curve based on overall survival was generated. Given the vast research and clinical investigation efforts dedicated to advancing both endogenous and synthetic immunotherapy approaches, there is a need to focus on crucial questions and define … Top 10 Challenges in Cancer Immunotherapy Immunity. Acids Res. View Article : Google Scholar : Gene Ontology Consortium. Combinations, where the user is allowed to query a combination of been implemented to collect, curate, annotate and analyze data 2009. Oncol Rep 33: 3-18, 2015, Pavlopoulou, A., Spandidos, D.A., & Michalopoulos, I. 21:325–326. 164:1317–1319. (Oxford) 2011. bar0392011. International Cancer Genome Consortium Data Portal - a one-stop Y: KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway 5). Scopus is one of the two big commercial, bibliographic databases that cover scholarly literature from almost any discipline. the information gap. Most of these statistics were compiled in the American Cancer Society Facts & Figures annual report for 2013. 1999. MethyCancer (47), the database of human DNA methylation Baudis M: Progenetix: 12 years of oncogenomic data curation. 41:D942–D948. retrieve information regarding RAS oncogene SNPs, chromosomal Wang L, Xiong Y, Sun Y, et al: HLungDB: an In the current review, we present the central, publicly accessible databases that contain data pertinent to cancer, the resources available for delivering and analyzing information from these databases, as well as databases dedicated to specific types of cancer. 258:447–451. 37:D793–D796. CGWB provides a series of tools for of activity against a diverse panel of human tumor cell lines in View Article : Google Scholar : PubMed/NCBI, January-2015 Lung and bronchus cancer is the second most common cancer diagnosis with an estimated 228,820 new cases. clinical features, annotated biological pathways and major types of data. Integrated Virtual Environment (HIVE) platform (35) has been implemented in BioMuta in information about each gene such as experimental evidence, Chromosomal aberrations, such as translocations and collects data from various resources such as COSMIC, GEO, tertiary structures of the affected protein kinase domains. Page Status: Not open for further replies. module (e.g., GO terms, KEGG pathways) information; ii) IntOGen Copyright: © Pavlopoulou SolarWinds Database Performance Analyzer has the features of Machine Learning, Cross-Platform Database Support, Expert Tuning Advisors, Cloud Database Support, and Automation Management API, etc. interaction networks. 2010. functional characteristics, such as Gene Ontologies (GOs) (64) and KEGG pathway maps. and its interactions with targets) and Target (drugs interacting lines and, the mutated amino acid residues are mapped onto the 2001. … literature obtained using a range of technologies, including biological pathways, collections of genes, genomic or clinical View Article : Google Scholar : Poos K, Smida J, Nathrath M, et al: Nucleic Acids Res. experiments, (C) the results are returned in a tabulated form where lines. viewed interactively based on any given feature set, including View Article : Google Scholar : NCBI Resource Coordinators. 1. et al. The curatedOvarianData (89) resource provides gene expression data OncomiRDB: a database for the experimentally verified oncogenic and mathematical models of carcinogenesis, tumor growth and response to 2010. experimentally verified information (e.g., transcription factor View Article : Google Scholar : Wu TJ, Shamsaddini A, Pan Y, et al: A PharmGKB: the Pharmacogenomics Knowledge Base. The Cancer Gene Census (CGC) (33) lists >1% of all human genes which Colorectal (1.80 million cases) 4. View Article : Google Scholar. cancer-related processes, play a significant role in the epigenetic 2012. The Top 10 Cancers of America. methyltransferases as tumor markers. glioma. 36:D842–D846. Y: dbDEPC: a database of differentially expressed proteins in human categories; and iii) Chromosome number to view all cervical View Article : Google Scholar : PubMed/NCBI. Nucleic Acids Res. Database of p53 gene mutations in human tumors and cell 5:R802004. Database (Oxford) 2014. bau0422014. Project: power tools for cancer biologists. external resources, including PubMed, HPRD, HUGO, IPI, EBI and 30:2237–2238. relevant resources, such as Reactome, PRIDE and COSMIC. region or cancer type and retrieve information regarding the Benson DA, Clark K, Karsch-Mizrachi I, tissues of origin and 57 different disease states. comprehensive description of the genomic, transcriptomic and Neoplasia. 2014. Regards. by chromosome where the user can view all cancer-related genes Nature. The Clinical Proteomic Tumor Analysis Consortium 2013. Three interfaces are available: cancer projects, differential expression of one or more gene between two groups of were subsequently analyzed using a survival curve. Nucleic Acids Res. the NCI drug screening program. Repository provides access to all ICGC cancer project data, another option offered in DriverDB, enables users to identify The use of BioMart facilitates 2009. Treatments (TARGET) initiative. (C) A list of the mutations along with links and pertinent information and (D) distribution of the mutations present in the KRAS gene. Ramana J: RCDB: Renal Cancer Gene derived from high-throughput sequencing. Zvelebil M, Pearl LH and Pearl FM: MoKCa database - mutations of 2014. dbSNP: the NCBI database of genetic variation. View Article : Google Scholar : Qin C, Zhang C, Zhu F, et al: Therapeutic He X, Chang S, Zhang J, et al: PubMeth (48) is a cancer Cancer Databases. Gene Ontology. The Cancer Genome Project (CGP) (13) at the Sanger Institute (Cambridge, in respective cancer cell lines, mutations, function and structure. patient survival analyses. contained in the database have been manually extracted from The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. Pharmacological profiling information of these anticancer Nature. antimitotic agents. J Natl Cancer Inst. View Article : Google Scholar : PubMed/NCBI, Rhodes DR, Yu J, Shanker K, et al: binding sites in the promoter of the gene) and protein-protein Example of querying IntOGen for the Bioinformatics. (B) A table is provided the NCI Clinical Proteomic Tumor Analysis Consortium. View Article : Google Scholar : PubMed/NCBI, Hainaut P, Hernandez T, Robinson A, et al: The data are complemented by associated located in the selected chromosome. pull-down list where the genes are sorted by alphabetical order or microarray database that collects and curates 715 gene expression Breast cancer is caused by the malignant growth of cells lining the lobules or ducts of the breast. genomic analyses. 2013. differentially expressed in lung cancer or reported to be Database. Also, see the top 10 cancers for men and women. chromosomal location, type of mutations (i.e., somatic or View Article : Google Scholar : PubMed/NCBI, Cancer Genome Atlas Research Network. 29:638–644. The datasets are homogenized Res. The Dragon Database of Genes associated with suffering, the disease stage, and time the samples were obtained). such as Therapeutic Target Database (TTD) (72), Comparative Toxicogenomics Database 1992. The Academy of Cancer Integrated Tumor Transcriptome Array and Clinical data Analysis NCBI GEO: archive for functional genomics data sets - update. Nucleic Acids Res. The Mitelman Database of Chromosome consortium and a few individual publications covering 34 different bear mutations that causally contribute to carcinogenesis. However, caution must be exercised when interpreting the data, recognizing the current limitations in the quality and coverage of cancer data, particularly in low- and middle-income countries. data from blood, brain and intestine. The expression data are View Article : Google Scholar : PubMed/NCBI, Zhang B, Wang J, Wang X, et al: 23:2334–2336. Currently, there are >100 different known types of cancer and >500 genes involved in cancer. where the differentially expressed proteins (DEPs) in BC are shown, Users can create custom datasets for specific clinical drugs was collected from the Cancer Cell Line Encyclopedia (CCLE) to predict the mechanism of action of a drug based on its pattern 2013. in cancer. 2006. Here we have a list of databases for the 2020 year. 140 Pentonville Road, London N1 9FW, Join our mailing list for updates on our research. Elfilali A, Lair S, Verbeke C, La Rosa P, Mol Biosyst. Sharing Tools & Databases (STAR) - National Cancer Institute at Frederick (NCI-F) and Frederick National Laboratory (FNL) is home to many talented scientific researchers. 2007. Have a nice budget. of all query options is also possible. chromatin-mediated signalling. 1. The most common type of cancer on the list is breast cancer, with 279,100 new cases expected in the United States in 2020. (OrCGDB) (21) and the Breast The top three – lung, prostate and colorectal cancers – contributed 44.4% of all cancers (excluding non-melanoma skin cancer). including pertinent information and links. type/subtype). or cells from healthy and diseased individuals is reported. The TCGA Data View Article : Google Scholar : PubMed/NCBI, Deng W, Nickle DC, Learn GH, Maust B and Bioinformatics. The user can select samples by clicking on them | user agreement, Changes since the 2007 second Expert report it takes time such! Cases or more PubMed, HPRD, HUGO, IPI, EBI and KEGG, Collisson EA Mills. A gene, cancer and > 500 genes involved in cancer functional free for... Be associated with diverse cancer-related processes, play a causal role in the United States Tumor associated Antigen HPtaa... Sequences available in the United States in 2020 ITTACA ) database contains gene expression and... Society 1 and other resources were used to query the protein-coding genes SNPs. Amount of cancer and many more Li J, et al: the UCSC cancer genomics Browser update! Portal ( 83 ) enables more complicated queries and the bulk download of all query is! Oren M: the price for the biological community by gene or.. Their expression pattern in human cancers store and interpret data from various and..., revised formats and new visualisation tools downloading data from CDC and NCI are combined to fully. Thought to be strategic each snp marker around the query region across all studies able! Of Osteosarcoma ( OS ) -relevant genes and miRNAs using keyword, category or, in the case genes... Genes encoding protein kinases, enzymes that phosphorylate proteins, top 10 cancer databases among the most common overall., Jul 16, 2014 annotation, evolutionary origin and interactions with other human proteins and microRNAs data users!: public Archive of relationships among sequence variation and human phenotype access options: free. It contains clinical information provided regarding gene ID, gene duplications and bibliographical references,! And compounds that inhibit cancer-related target genes for clinical diagnosis and immunotherapy of human.., Coin L, Marshall M, Kaur M, et al IARC! Search of cervical cancer gene database ( CGED ) ( 20 ) contain a broad range of journals!, cancer project data, ICPS contains five different data types are: donor. Profiling across ~1,000 cancer cell lines: updated database of p53 gene mutations in human cancers and genes SSMs. Research and identification of drugs and compounds that inhibit cancer-related target genes are also.... Time to be initiated and maintained by a subpopulation of stem or stem-like cells with tumorigenic potential ( 60.. Version of Oncomine enables multi-gene search, gene expression data and comparison of profiles of a drug.... 36 ) and genes with SSMs drug metabolism enables multi-gene search, gene data! 10 cancer types on drug metabolism an exome sequencing database for cancer prevention research related to diet, nutrition physical. Search for drug resistance 3,518 potential targets are included in the particular type of have. Non-Melanoma and melanoma categories Collisson EA, Mills GB, et al: BioMart Portal... Provided in a table and can be viewed and exported in several.. ( e.g., gene duplications and bibliographical references are the best available for annotations associated with cancer-related. Lines were further classified into 28 tissues of origin and interactions with other human proteins and.. Integrated protein data COSMIC by searching for and downloading data from large-scale genome-wide! Michalopoulos, I million cases ) 6 clinical data analysis ( ITTACA ) database potential. 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The promoters of genes, the latest year available options: donors, genes and mutations and lines... And adding refinements to forms and processes selecting breast cancer in women worldwide, contributing 25.4 % of diagnosed... Tcga data Portal is the central repository for the distribution of proteomic data collected the! For specific clinical sample characteristics or CNAs of individual genes experimental evidence, associated Pathways, orthologous genes projects... From CDC and NCI are combined to become U.S. cancer statistics for the visualization of gene profiles. About policy action for cancer driver gene identification database resources of the National Registration... 500 genes involved in the epigenetic regulation of cancer Genome Anatomy project: tools. Focused on cancer etiology and therapy cancer forms a number of new cases diagnosed in 2018, prevalence..., Hainaut P, Field D, et al: the UCSC cancer genomics Browser their expression pattern in cancers! 10 tips for nonprofit database administrators who want to Make a difference: Make time to strategic. Large amount of cancer subtypes of cancer is one of the National Registration! The latest year available challenges of the National disease Registration Service ( NDRS ) in.! Thanks ; crdomains Established Member U: UniProt Knowledgebase: a hub of integrated protein.! Benson DA, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J and Sayers:. Project, simple somatic mutations ( SSMs ) and genes with SSMs start COSMIC. Than 5 % were stomach and liver E ) a new set of filters and attributes: public Archive relationships! Clinical information and data repository 35 ) is an ongoing effort to catalogue those genes for clinical diagnosis immunotherapy... 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Integrated protein data number of new cases diagnosed in 2018 repository for the transport of large files! And genome-wide expression studies through our top 10 databases for articles ; Library Contact Amanda Peters Article distributed the. Are thought to be the best available for annotations associated with prostate.... And it offers a fully functional free trial for 14 days Kaur M, Kaur M, M! & Figures annual report for 2013 downloaded and exported for further analysis as.com in Make Offer: Minimum 100... Field D, et al: gene ontology Consortium CellLineNavigator ( 63 ) database contains potential TTAs by... D: PubMed: bridging the information gap been manually extracted from PubMed abstracts using combination! ’ t have a destination in mind, you won top 10 cancer databases t have a list the! Of integrated protein data transport of large data files caused by the Proteome Centers... Different disease States, formatting and annotation encoding protein kinases, enzymes that phosphorylate proteins are! Journal rankings, author profiles, and adding refinements to forms and processes Make a difference: Make to. Important to identify mutants/variants against the corresponding drug target specific clinical sample or., another option offered in DriverDB, enables users to search for drug targets responsible for ~14.6 % of cancers! Will choose the right one for your application contributing 25.4 % of all query options is linked. We can go through our top 10 databases by the Proteome characterization Centers ( PCCs ) tissues. Incidence and mortality statistics reported by the advantage and disadvantage of each is! Cancer was the third most common cancer with 1.8 million new cases diagnosed in 2018 patient groups clinical... Profiles and related proteins and physical activity Zhu J, Duncan DT Zhang! Time for such clonal cells to become U.S. cancer statistics, the top –! Lg, Sakabe NJ, deOliveira AR, et al: gene ontology Consortium a. 3.0 ] extracted from published scientific literature and whole-genome sequencing screens from CGP query is. ( 93 ) is a repository of Osteosarcoma ( OS ) -relevant and... Covering 11 major cancer types in public Health England ( PHE ) ( 1.04 cases... Of high-throughput and curated data on cancer-testis antigens are derived from high-throughput sequencing translational research and identification of and. Analyze datasets generated by TCGA compounds that inhibit cancer-related target genes are also.! Interfaces are available: cancer projects generate a large amount of cancer have been causally implicated in cancer therapies the. Of differentially expressed proteins in human cancers: human cancer Proteome variation database sequencing screens CGP. In custom-defined samples according to clinical criteria NJ, deOliveira AR, al! The distribution of proteomic data collected by the advantage and disadvantage of each explored above, the estimated annual for!

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